Increasing weakness and atrophy of the lower extremities were documented by clinical examination and by c. Hyperkalemic periodic paralysis hypp, hyperkpp is an inherited autosomal dominant disorder that affects sodium channels in muscle cells and the ability to regulate potassium levels in the blood. A study of thyroid pituitary relations to familial periodic paralysis has been completed recently by engel 28, also utilizing this familial periodic paralysis 55 family. Hypokalemic paralysis in emergency department a case report. The patients paralysis resolved upon repletion of his low potassium and he was. Mesh terms adult female humans paralyses, familial periodic diagnosis. A case report find, read and cite all the research you need on researchgate.
It is vital for physicians to be able to differentiate tpp from familial. Morbidity and mortality associated with unrecognized disease can occur and include respiratory failure and possibly death. Propofol and atracurium in familial periodic paralysis. Moussac and salah gariballaa the objective of this study was to present a case series of adequately addressed to prevent the persistence or patients with hypokalemic periodic paralysis. Hypokalemic periodic paralysis is a rare disorder in which a person experiences episodes of painless muscle weakness and often paralysis. In individuals with this mutation, attacks sometimes begin in adolescence and most commonly occur with individual triggers such as rest after. It is vital for physicians to be able to differentiate tpp from familial hypokalemic periodic paralysis, a more common cause of periodic paralysis in caucasians and western countries. The present article was aimed to study demographic and clinical pattern, periodicity and precipitating events for hypokalemic paralysis and to assess the. Sep 15, 2015 a history of paralysis, hyperthyroidism, or use of insulin or beta agonists. Familial periodic paralysis was recognized as clinical entity as early as the end of the nineteenth century. Get a printable copy pdf file of the complete article 176k, or click on a page image below to browse page by page. Jun 01, 2018 1 it is a disorder most commonly seen among asian males. This 45yearold woman had neither periodic paralysis nor epileptic seizures or tremor. Observations on a case of familial periodic paralysis.
Adas c, utku u, utku b, adas h 2014 hypokalemic periodic paralysis cases. Study in two patients with familial periodic paralysis and in one with non familial periodic paralysis of potassium movement and associated changes in muscle function yielded the following results. Periodic paralysis is a group of heterogeneous disorders of different etiologies, with episodic, shortlived, and hyporeflexic skeletal muscle weakness, with or without myotonia. Change in muscle strength determined with manual muscle. It is characterised by recurrent attacks of muscle weakness or flaccid paralysis occasionally associated with abnor mality of the serum potassium. We describe a 19yearold caucasian man who presented with acute onset lower extremity paralysis secondary to acute hypokalemia and was found to have new onset. Campanile s, montagna p, agati r, campanile a, lorusso s. Blog without the luxury of a onesizefitsall product, virtual receptionist company answer 1 tackles customer service and marketing with a uniquely diversified target audience.
Pdf on apr 30, 2019, blessy rachal boban and others published hypokalemic periodic paralysis. Periodic paralysis study reveals gene causing disorder. Between attacks, the affected muscles usually work as normal. Familial hypokalemic periodic paralysis hypothermia inadequate intake anorexia dementia starvation. There is a marked hypokalemia during the paralytic episodes of the disease, and a family history in 80 percent of the cases.
They are characterized by episodes in which the affected muscles become slack, weak, and unable to contract. Knowledge of its occurrence during pregnancy is scanty but there is one reported case of tpp manifesting after abortion 8. Familial periodic paralysis is a disease of unknown etiology characterized by recurrent acute attacks of weakness associated with a fall in serum potassium levels. Clinical profile in hypokalemic periodic paralysis cases electronic. Before sharing sensitive information, make sure youre on a federal government site.
Familial hypokalaemic periodic paralysis fhpp is an inherited condition characterized by ypokalaemia and limb. For the last 2 years he had the same episodes with spontaneous recovery. Bipolar disorder cooccurring with periodic paralysis. A 20yearold male was brought to the hospital with the complaints of severe weakness and inability to move the limbs of 12 hours duration. In summary, this study suggests that a subgroup of persons with periodic paralysis may have a prominent sleep disorder resembling narcolepsy, but distinct from narcolepsy in that an alteration in neuronal potassium conductance rather than an alteration in the hypocretin pathway, like in narcolepsy is the most likely cause of the altered rem. Hypokalemic periodic paralysis hypokpp, also known as familial hypokalemic periodic paralysis fhpp, is a rare, autosomal dominant channelopathy characterized by muscle weakness or paralysis when there is a fall in potassium levels in the blood. Hypokalemic periodic paralysis case insight medical. A case of familial periodic paralysis westphals disease. Familial periodic paralysis is a rare autosomal dominant condition with considerable variation in penetrance characterized by episodes of flaccid paralysis with loss of deep tendon reflexes and failure of muscle to respond to electrical stimulation.
Pdf study of incidence and prevalence of hypokalemic. There is neither sensory deficit nor loss of consciousness. A case of hypokalemic periodic paralysis, is reported, characterized by a positive family history and by repeated attacks of transient motor weakness since the age of 14 involving one all limbs. Common causes of hypokalemic paralysis include thyrotoxic periodic paralysis tpp which is a disorder most freque. May 30, 2012 hypokalemic periodic paralysis free download as powerpoint presentation. An engaged profile on consumeraffairs builds trust with consumers by showi. A list of case studies involving the fda tv studio. Jun 01, 1978 journal ojthe neurological sciences, 1978, 37. With large potassium supplements and ageing, the number and severity of attacks became considerably reduced. Familial periodic paralysis has been associated with mutations of voltagegated sodium channels, the ltype calcium channels, or inward rectifier potassium channels 6.
Journal of contraceptive studies imedpub journals 2016. This 42yearold man had periodic episodes of generalized paralysis since 15 years of age, caused by stress or exercise. Gly387arg in an individual with familial periodic paralysis using exome sequencing. It is vital for physicians to be able to differentiate tpp from familial hypokalemic periodic paralysis, a more common cause of periodic paralysis in. A 51 yearold male patient was affected by a dominantly inherited periodic paralysis. Jun 19, 2019 familial hypokalemic periodic paralysis f. Treatment of thyrotoxicosis is adequate to prevent recurrent. The skeletal muscles are affected and the bulbar muscles spared. Clinical subtypes of periodic paralysis have been defined on the basis of the serum potassium levels during an attack, associated provocative triggers, and the coexistence of. Familial periodic paralyses child neurology foundation. Hypokalemic periodic paralysis is one form of periodic paralysis, a rare group of disorders that can cause of sudden onset weakness. Hypokalemic periodic paralysis case journal of reproductive. Cacna1s arg528cys mutation in a young chinese man with. It was first described by cavare 1853, whose findings have been supplemented by studies of.
Laboratory evaluation revealed a markedly low potassium level. Overview of all products overview of free tools marketing automation software. Paralysis must differentiated from other causes of weakness and paralysis so that the proper treatment can be initiated. Periodic paralysis an overview sciencedirect topics. The list represents suggestions from ppa members or correspondents and does not represent an endorsement of the physicians or institutions appearing in the list by the ppa. Periodic paralysis is an autosomal dominant myopathy with considerable variation in penetrance, leading to a spectrum of familial phenotypes only one parent needs to carry the gene mutation to affect the children, but not all family members who share the gene are affected to the same degree. Hypokalemic periodic paralysis case insight medical publishing. This study has been presented for the consideration of the rare hypopp in patients presenting with sudden muscle weakness. Jun 12, 2017 the periodic paralysis association ppa has a find a doctor page where you can view a list of physicians who specialize in periodic paralysis. Observations on a case of familial periodic paralysis j assoc physicians india. Orrico universita degli studi di padova, sede di verona clinica neurologica, centro ospedali ro clinicizzato, borgo roma, verona italy received 28 december, 1977 accepted. Familial hypokalemic periodic paralysis with myotonic. Case histories and muscle biopsy findings are reported of two members of a family suffering from hypokalaemic periodic paralysis associated with permanent muscular weakness. Oct 21, 2008 hypokalemic periodic paralysis is one form of periodic paralysis, a rare group of disorders that can cause of sudden onset weakness.
Familial periodic paralysis is an hereditary condition thought to be transmitted by an autosomal dominant gene. Theassociation with familial periodic paralysis is of particular genetic interest, since the latter is also anautosomaldominantdisease. A decreased in blood potassium levels during attacks of periodic paralysis was described in 1934 by biemond and daniels, and founded the basis for the first classification of periodic paralysis 2,3. All patients with hypokalemic periodic paralysis should be tested for thyrotoxicosis. Waardenburgs syndrome and familial periodic paralysis. The familial disorder, hypokalemic periodic pa ralysis, is the longest known and most frequent form of periodic paralysi. Jan 01, 1999 tpp is indistinguishable from idiopathic familial periodic paralysis except there is a higher propensity for dysrhythmias, cardiac arrest, and respiratory failure 6, 7. Periodic paralysis pp is a muscle disease that causes episodic muscle weakness, in the family of diseases called channelopathies.
Wong p 2003 hypokalemic thyrotoxic periodic paralysis. Secondary periodic paralysis is due to demonstrably known causes. Full text full text is available as a scanned copy of the original print version. The authors studied 8 patients with familial periodic paralysis on the clinical, hydroelectrolytic, electrophysiologic, histologic and therapeutic points of view. None of these congenital anomalies has been previously documented.
Hypokalemic periodic paralysis genetic and rare diseases. Although rare, periodic paralysis must differentiated from other causes of weakness and paralysis so that the proper treatment can be initiated. Che metcalfe got so fed up with the limitations of mobile phones and network operators for distributing content that he built a network platform of his own che metcalfe got so fed up with the limitations of mobile phones and network operato. Mutations linked to familial hypokalaemic periodic paralysis in the calcium channel alpha1 subunit gene cav1. Familial hypokalemic periodic paralysis in pregnancy. The familial periodic hypokalemic paralysis is an infrequent disease characterized by paralytic attacks of sudden appearance affecting the muscles of the trunk and limbs. Most often, these episodes involve a temporary inability to move muscles in the arms and legs. Hyperkalemic periodic paralysis is a condition that causes episodes of extreme muscle weakness or paralysis, usually beginning in infancy or early childhood. Familial periodic paralysis associated with a rare kcnj5. When youre performing research as part of your job or for a school assignment, youll probably come across case studies that help you to learn more about the topic at hand. Increasing weakness and atrophy of the lower extremities.
Familial periodic paralysis pediatrics merck manuals. Thyrotoxic periodic paralysis tpp is one of three types of periodic paralysis, a rare group of disorders that can cause of sudden onset weakness 1. Get a printable copy pdf file of the complete article 109k, or click on a page image below to browse page by page. Acute hypokalemic paralysis is a rare cause of acute weakness. The syndrome of acute andor repeated paresis, however, can be brought on by a variety of factors, which must be distinguished from those in familial periodic paralysis.
Thyrotoxic periodic paralysis in an adolescent male. Recent studies suggested that variants in kcnj5 are also causative for andersentawil syndrome, which showed periodic paralysis and characteristic electrocardiogram features. How to do an executive summary on a case study bizfluent. Sleep complaints in periodic paralysis periodic paralysis intl.
Two of the episodes were observed in our hospital and mild hypokalemia. Blog leading walkin bathtub manufacturer independent home finds continued success and increased customer satisfaction with a dedicated reputation management effort. Early hypotheses on the pathogenesis of periodic paralysis included the theory of muscleischemia asthe underlyingpathology westphal, 1885, holtzapple, 1905, schmidt, 1919, mankowsky, 1929. Studies in familial periodic paralysis sciencedirect. She had the history of polymyositis diagnosis and the use of deltacortril and. It is characterized by muscle hyperexcitability or weakness which, exacerbated by potassium, heat or cold, can lead to uncontrolled shaking followed. Get inspiration for your next case study with these successful examples from real brands. It is the purpose of this communication to correlate all these studies in these particular patients, and to interpret such findings in the light of present concepts of this.
An executive summary of a business case study is a powerful, condensed version of the study itself containing enough compelling information that your audience will want to read the full report. The patient presented with sudden onset paralysis of his extremities. Nov 23, 2020 tpp is commonly misdiagnosed in western countries because of its similarities to familial periodic paralysis. It resolves with treatment of the underlying thryrotoxicosis. By partnering with consumeraffairs, answer 1 was able to conne. It is classified as hypokalemic when episodes occur in association with low potassium blood levels or as hyperkalemic when episodes can be induced by elevated potassium. The contractile ap paratus of the afflicted muscle fibers is normal and the cause of paralysis was suggested to be inex citability due to membrane depolariation. Clinical, humoral and electromyographic study during induced paralytic attacks. Experimental procedure and methods the patients studied were 2 of the 3 cases of familial periodic paralysis which have.
Studies on a patient with hypokalemic familial periodic. Consultant neuropsychiatrist, british military hospital, colombo familial periodic paralysis presents a welldefined clinical picture. Jul 01, 1995 conflicting studies argue whether there is an influx of potassium into muscle cells sufficient to cause both weakness and serum hypokalemia. Lithium therapy has already been proposed in various forms of familial periodic paralysis like hypokalemic, hyperkalemic, and hypermagnesemic paralysis, with varying results.
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